1315 Maternal Preferences with Regard to Indomethacin Prophylaxis vs Treatment Options in Preterm Infants

Ibuprofen vs indomethacin for treatment of PDA in preterm infants.

Forty preterm infants (<33 weeks) with respiratory distress syndrome (RDS) and echocardiographically confirmed PDA were randomly assigned at days 2 and 3 of life to receive either intravenous indomethacin in a dose of 0.2 mg/kg for three doses at 12 hourly intervals, or intravenous ibuprofen 10 mg/kg followed by two more doses of 5 mg/kg administered at 24 and 48 hours after the first dose. All...

A prospective study of maternal preference for indomethacin prophylaxis versus symptomatic treatment of a patent ductus arteriosus in preterm infants

BACKGROUND The management of a patent ductus arteriosus in preterm infants continues to be debated among neonatologists due to the absence of concrete evidence that precisely weighs the long term outcomes of active, early intervention against a conservative approach. In the majority of institutions, parents are encouraged to play an active role in the complex, decision -making processes with re...

Early administration of indomethacin to preterm infants.

Indomethacin (0.2 mg/kg) or saline was given intravenously during the first 24 hours to 50 preterm infants in a double blind controlled trial. Eight of the control group later required treatment with indomethacin for clinical signs of left to right shunt, but only one in the treatment group (p = 0.03). Treatment with indomethacin prolonged bleeding time, raised serum creatinine concentrations, ...

Effects of Perinatal Indomethacin Treatment on Preterm Infants

A decision aid for considering indomethacin prophylaxis vs. symptomatic treatment of PDA for extreme low birth weight infants

BACKGROUND Decision Aids (DA) are well established in various fields of medicine. It can improve the quality of decision-making and reduce decisional conflict. In neonatal care, and due to scientific equipoise, neonatologists caring for extreme low birth weight (ELBW) infants are in need to elicit parents' preferences with regard to the use of indomethacin therapy in ELBW infants. We aimed to d...